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He had already synthesized the uterine contractant ergonovine in 1936, and the chemical structure of the new compound suggested mejor viagra cialis o levitra cost potential respiratory and circulatory stimulant. He designated if LSD-25, because it was the twenty-fifth compound of the viagra originally developed for acid amide series. It was tested on animals, but Sandoz pharmacologists did not find the results interesting enough to pursue. Hofmann did not lose interest, however, and on April 16, 1943, he prepared a fresh batch. As it crystallized, a trace was absorbed through the skin of his fingers, and he had a mild psychedelic experience. Three days later, on April 19, he swallowed 250 micrograms, planning to raise the dose gradually, since no substance known at the time was active in such small quantities.

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Compared to modern humans, the Homo erectus brain case was more elongated from front to back and less spherical. As a consequence, the frontal and temporal lobes of their brains were narrower, suggesting that they would have had somewhat lower mental ability. The adult Homo erectus brain size ranged from around 750 to 1250 cm 3averaging about 930 cm 3. This was only around 69 the size of modern human brains on average but 50 larger than Homo habilis. The upper end of the Homo erectus brain size range overlapped that of modern people.

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